|
EDITORIAL
|
4725-4725
| Web Submission of Letters To Replace Communications
Philip S. Portoghese
Editor-in-Chief
[Full Article -
PDF] | |
ARTICLES
|
4726-4737
Synthesis and Structure-Activity Relationships of Chiral Allosteric Modifiers of Hemoglobin
Melissa Phelps Grella,
Richmond Danso-Danquah,
Martin K. Safo,
Gajanan S. Joshi,
Jean Kister,
Michael Marden,
Stephen J. Hoffman, and
Donald J. Abraham
[Full Article -
PDF]
| |
4738-4746
Ethylene Glycol and Amino Acid Derivatives of 5-Aminolevulinic Acid as New Photosensitizing Precursors of Protoporphyrin IX in Cells
Yann Berger,
Alain Greppi,
Olivier Siri,
Reinhard Neier, and
Lucienne Juillerat-Jeanneret
[Full Article -
PDF]
| |
4747-4758
Inhibition of Monoamine Oxidases by Functionalized Coumarin Derivatives: Biological Activities, QSARs, and 3D-QSARs
Carmela Gnerre,
Marco Catto,
Francesco Leonetti,
Peter Weber,
Pierre-Alain Carrupt,
Cosimo Altomare,
Angelo Carotti, and
Bernard Testa
[Full Article -
PDF]
| |
4759-4767
Protein-Based Virtual Screening of Chemical Databases. 1. Evaluation of Different Docking/Scoring Combinations
Caterina Bissantz,
Gerd Folkers, and
Didier Rognan
[Full Article -
PDF]
| |
4768-4780
Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine Derivatives as Highly Potent and Selective Human A3 Adenosine Receptor Antagonists: Influence of the Chain at the N8 Pyrazole Nitrogen
Pier Giovanni Baraldi,
Barbara Cacciari,
Romeo Romagnoli,
Giampiero Spalluto,
Stefano Moro,
Karl-Norbert Klotz,
Edward Leung,
Katia Varani,
Stefania Gessi,
Stefania Merighi, and
Pier Andrea Borea
[Full Article -
PDF]
| |
4781-4786
Design of Adenosine Kinase Inhibitors from the NMR-Based Screening of Fragments
Philip J. Hajduk,
Arthur Gomtsyan,
Stanley Didomenico,
Marlon Cowart,
Erol K. Bayburt,
Larry Solomon,
Jean Severin,
Richard Smith,
Karl Walter,
Thomas F. Holzman,
Andrew Stewart,
Steve McGaraughty,
Michael F. Jarvis,
Elizabeth A. Kowaluk, and
Stephen W. Fesik
[Full Article -
PDF]
| |
4787-4792
Chemical Syntheses and Biological Activities of Lactam Analogues of  -Conotoxin SI
Balazs Hargittai,
Núria A. Solé,
Duncan R. Groebe,
Stewart N. Abramson, and
George Barany
[Full Article -
PDF]
| |
4793-4800
Semisynthesis of Antitumoral Acetogenins: SAR of Functionalized Alkyl-Chain Bis-Tetrahydrofuranic Acetogenins, Specific Inhibitors of Mitochondrial Complex I
Teresa Gallardo,
M. Carmen Zafra-Polo,
José R. Tormo,
M. Carmen González,
Xavier Franck,
Ernesto Estornell, and
Diego Cortes
[Full Article -
PDF]
| |
4801-4805
N4-( -Aminoalkyl)-1-[(-aminoalkyl)amino]-4-acridinecarboxamides: Novel, Potent, Cytotoxic, and DNA-Binding Agents
Ippolito Antonini,
Paolo Polucci,
Lloyd R. Kelland,
Silvano Spinelli,
Nicoletta Pescalli, and
Sante Martelli
[Full Article -
PDF]
| |
4806-4811
Synthesis and Antitumor Activities of Novel Pyrimidine Derivatives of 2,3-O,O-Dibenzyl-6-deoxy-L-ascorbic Acid and 4,5-Didehydro-5,6- dideoxy-L-ascorbic Acid
Silvana Rai -Mali,
Dra enka Svedrui,
Tatjana Gazivoda,
Andreja Marunovi,
Antonija Hergold-Brundi,
Ante Nagl,
Jan Balzarini,
Erik De Clercq, and
Mladen Mintas
[Full Article -
PDF]
| |
4812-4821
(2,2':6',2' '-Terpyridine)platinum(II) Complexes Are Irreversible Inhibitors of Trypanosoma cruzi Trypanothione Reductase But Not of Human Glutathione Reductase
Susanne Bonse,
Jonathan M. Richards,
Steven A. Ross,
Gordon Lowe, and
R. Luise Krauth-Siegel
[Full Article -
PDF]
| |
4822-4833
Non-depolarizing Neuromuscular Blocking Activity of Bisquaternary Amino Di- and Tripeptide Derivatives
Leo H. D. J. Booij,
Leon A. G. M. van der Broek,
Wilson Caulfield,
Brigitte M. G. Dommerholt-Caris,
John K. Clark,
Jan van Egmond,
Ross McGuire,
Alan W. Muir,
Harry C. J. Ottenheijm, and
David C. Rees
[Full Article -
PDF]
| |
4834-4839
Synthesis and Evaluation of Pharmacological and Pharmacokinetic Properties of 11H-[1,2,4]Triazolo[4,5-c][2,3]benzodiazepin-3(2H)-ones
Maria Zappalà,
Rosaria Gitto,
Francesca Bevacqua,
Silvana Quartarone,
Alba Chimirri,
Milena Rizzo,
Giovambattista De Sarro, and
Angela De Sarro
[Full Article -
PDF]
| |
4840-4849
Synthesis and Transporter Binding Properties of Bridged Piperazine Analogues of 1-{2-[Bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine (GBR 12909)
Ying Zhang,
Richard B. Rothman,
Christina M. Dersch,
Brian R. de Costa,
Arthur E. Jacobson, and
Kenner C. Rice
[Full Article -
PDF]
| |
4850-4867
Synthesis, Structure-Activity Relationships, and Pharmacological Profile of 9-Amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6,7,1-hi]indoles: Discovery of Potent, Selective Phosphodiesterase Type 4 Inhibitors
Catherine Burnouf,
Eric Auclair,
Nadine Avenel,
Bernadette Bertin,
Christèle Bigot,
Alain Calvet,
Kam Chan,
Corinne Durand,
Veronique Fasquelle,
Frédéric Féru,
Richard Gilbertsen,
Henry Jacobelli,
Adel Kebsi,
Emmanuelle Lallier,
Jacquie Maignel,
Brigitte Martin,
Stéphane Milano,
Malika Ouagued,
Yves Pascal,
Marie-Pierre Pruniaux,
Jocelyne Puaud,
Marie-Noëlle Rocher,
Christophe Terrasse,
Roger Wrigglesworth, and
Annette M. Doherty
[Full Article -
PDF]
| |
4868-4876
Design, Synthesis, and Monoamine Transporter Binding Site Affinities of Methoxy Derivatives of Indatraline
Xiao-Hui Gu,
Han Yu,
Arthur E. Jacobson,
Richard B. Rothman,
Christina M. Dersch,
Clifford George,
Judith L. Flippen-Anderson, and
Kenner C. Rice
[Full Article -
PDF]
| |
4877-4883
Synthesis and Antitumor Activity of Thieno-Separated Tricyclic Purines
Katherine L. Seley,
Piotr Januszczyk,
Asmerom Hagos, and
Liang Zhang
, Daniel T. Dransfield
[Full Article -
PDF]
| |
4884-4892
Carbonic Anhydrase Inhibitors: Water-Soluble 4-Sulfamoylphenylthioureas as Topical Intraocular Pressure-Lowering Agents with Long-Lasting Effects
Angela Casini,
Andrea Scozzafava,
Francesco Mincione,
Luca Menabuoni,
Marc A. Ilies, and
Claudiu T. Supuran
[Full Article -
PDF]
| |
4893-4909
Synthesis, SARs, and Pharmacological Characterization of 2-Amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Derivatives as Potent, Selective, and Orally Active Group II Metabotropic Glutamate Receptor Agonists
Atsuro Nakazato,
Toshihito Kumagai,
Kazunari Sakagami,
Ryoko Yoshikawa,
Yoshiko Suzuki,
Shigeyuki Chaki,
Hisanaka Ito,
Takeo Taguchi,
Shigetada Nakanishi, and
Shigeru Okuyama
[Full Article -
PDF]
| |
4910-4918
Structural Determinants of AMPA Agonist Activity in Analogues of 2-Amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic Acid: Synthesis and Pharmacology
Benny Bang-Andersen,
Haleh Ahmadian,
Sibylle M. Lenz,
Tine B. Stensb l,
Ulf Madsen,
Klaus P. Bges, and
Povl Krogsgaard-Larsen
[Full Article -
PDF]
| |
BRIEF ARTICLES
|
4919-4922
Synthesis of Apicidin-Derived Quinolone Derivatives: Parasite-Selective Histone Deacetylase Inhibitors and Antiproliferative Agents
Peter T. Meinke,
Steven L. Colletti,
George Doss,
Robert W. Myers,
Anne M. Gurnett,
Paula M. Dulski,
Sandra J. Darkin-Rattray,
John J. Allocco,
Stefan Galuska,
Dennis M. Schmatz,
Matthew J. Wyvratt, and
Michael H. Fisher
[Full Article -
PDF]
| |